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KMID : 0858420120140010029
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Korean Journal of Stroke
2012 Volume.14 No. 1 p.29 ~ p.34
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Difference in Infarct Volume and Initial Clinical Severity between Stroke Patient with Patent Foramen Ovale and Atrial Fibrillation
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Hong Chang-Gi
Kim Il-Gon
Lee Jeong
Choi Yoon-Jae
Ryoo Na-Young
Rha Joung-Ho
Park Hee-Kwon
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Abstract
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Atrial fi brillation (AF) and patent foramen ovale (PFO) are established sources of cardioembolism. We investigated differences in stroke outcome and patterns between PFO and AF.
Methods: We performed a retrospective review of the medical records and brain MR images of patients with AF or PFO from the prospective acute stroke and transient ischemic attack registry. Infarct pattern and volume on diffusion-weighted imaging, and the national institutes of health stroke scale (NIHSS) on admission were compared between patients with AF and PFO.
Results: From June 2005 to July 2008, a total of 289 subjects were enrolled (AF group, n=156; PFO group, n=133). Infarct pattern analyzed with MR images revealed that multiple vascular territorial infarction was more prevalent in AF group than in PFO group (26.9% vs. 8.3%, P <0.01). A probable cardiac embolism, radiologically defi ned as territorial infarction without symptomatic steno-occlusion of the corresponding artery, was more frequently documented in AF group than in PFO group (71.8% vs. 41.4%, P <0.01) The infarct volume of PFO was smaller than that of AF. Compared to AF, PFO was associated with the mild neurologic defi cit (NIHSS≤3) after adjusting age, sex and previous stroke history. Conclusion: These results suggested that AF and PFO had different characteristics such as infarct patterns and initial clinical severity although both are classifi ed as cardioembolism. (Korean J Stroke 2012;14:29-34)
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KEYWORD
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Atrial fi brillation, Patent foramen ovale, Stroke
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